Medium chain triglycerides alleviate non-alcoholic fatty liver disease through bile acid-mediated FXR signaling pathway: A comparative study with common vegetable edible oils.
We investigated the effects of medium-chain triglycerides (MCTs) on non-alcoholic fatty liver disease (NAFLD) induced by obesity. By treating mice with various dietary fats over 16 weeks, we observed that MCTs significantly improved weight and blood lipid levels, and reduced liver fat more effectively than traditional vegetable oils. Significant changes in bile acid composition were also noted, with MCTs promoting beneficial FXR signaling. Overall, MCTs demonstrated a promising potential in managing NAFLD, offering a better option than common long-chain oils.
Read More
2
MCT oil may harm liver health
Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice.
We explored how medium-chain triglyceride (MCT) oil affects liver health, particularly regarding damage caused by high fructose intake in mice. Over 12 weeks, we divided young mice into four groups to assess various health markers.
Surprisingly, we found that both groups receiving MCT oil exhibited liver issues, despite the expectation of improvement. The mice consuming fructose with MCT oil did not worsen the liver damage but still showed notable signs of hepatic steatosis and inflammation.
Overall, our findings suggest that MCT oil might lead to harmful liver effects, emphasizing the need for caution in its use, especially when liver health is already compromised.
Read More
9
MCT oil improves GSD-1 outcomes
Medium-Chain Triglyceride Oil and Dietary Intervention Improved Body Composition and Metabolic Parameters in Children with Glycogen Storage Disease Type 1 in Jordan: A Clinical Trial.
We examined how medium-chain triglyceride (MCT) oil, combined with a specialized diet, influences children suffering from glycogen storage disease type 1 (GSD-1) in Jordan.
Over three months, we assessed 38 children and observed a dramatic reduction in hypoglycaemia, from nearly 95% to about 8%. There were also significant drops in triglycerides, cholesterol, and uric acid levels.
Importantly, we noted improvements in liver size and various growth parameters, indicating that MCT oil can positively impact metabolic health in this population.
Read More
Most Useful Reviews
9
Boosted daily energy
7 people found this helpful
It was astonishing from the very first spoon! I truly loved it. Its effect was evident immediately. Taking it on an empty stomach in the morning increased my energy levels throughout the day. It's excellent for athletes and anyone aiming to lose weight as it aids in entering ketosis swiftly. It's tasteless and easily digestible, making it perfect for those with liver disease and gallbladder issues. I experienced deep sleep and great concentration the following day after consuming it. However, it can act as a laxative in large doses, so I recommend starting slowly.
Read More
7.5
Easy absorption noted
6 people found this helpful
I highly recommend this oil; it does not hinder the body's absorption process as it passes directly through the liver, making it beneficial, according to a friend of mine.
Read More
9
Excellent training aid
This exceptional oil serves as a great alternative to many traditional oils and energy drinks. Packed with healthy fats, it’s absorbed in the intestines and goes directly to the liver, providing immediate energy. Taking a tablespoon before exercising significantly enhances my strength for workouts. I also enjoy adding it to smoothies, with its delicious coconut flavour and excellent quality.
Medium chain triglycerides alleviate non-alcoholic fatty liver disease through bile acid-mediated FXR signaling pathway: A comparative study with common vegetable edible oils.
We investigated the effects of medium-chain triglycerides (MCTs) on non-alcoholic fatty liver disease (NAFLD) induced by obesity. By treating mice with various dietary fats over 16 weeks, we observed that MCTs significantly improved weight and blood lipid levels, and reduced liver fat more effectively than traditional vegetable oils. Significant changes in bile acid composition were also noted, with MCTs promoting beneficial FXR signaling. Overall, MCTs demonstrated a promising potential in managing NAFLD, offering a better option than common long-chain oils.
Read More
9
MCT oil improves GSD-1 outcomes
Medium-Chain Triglyceride Oil and Dietary Intervention Improved Body Composition and Metabolic Parameters in Children with Glycogen Storage Disease Type 1 in Jordan: A Clinical Trial.
We examined how medium-chain triglyceride (MCT) oil, combined with a specialized diet, influences children suffering from glycogen storage disease type 1 (GSD-1) in Jordan.
Over three months, we assessed 38 children and observed a dramatic reduction in hypoglycaemia, from nearly 95% to about 8%. There were also significant drops in triglycerides, cholesterol, and uric acid levels.
Importantly, we noted improvements in liver size and various growth parameters, indicating that MCT oil can positively impact metabolic health in this population.
Read More
9
MCT reduces alcohol-related liver fat
Preservation of hepatocyte nuclear factor-4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats.
We examined the effects of medium chain triglycerides (MCT) on liver health, particularly in the context of alcohol consumption. Over eight weeks, male rats were fed diets containing control, alcohol, and MCT with alcohol.
The results showed that MCT reduced liver fat accumulation linked to alcohol while preserving critical liver proteins. MCT helped balance the fatty acid levels and normalized several liver genes affected by alcohol.
Ultimately, we found that MCT could offer liver protection from the harmful effects of alcohol by maintaining important cellular functions.
Read More
9
MCT oil improves liver fat
Rapid reduction of liver steatosis in omega3-depleted rats injected with a novel lipid emulsion.
We examined the effects of a novel medium-chain triglyceride and fish oil emulsion on liver fat in omega-3-depleted rats. By injecting this emulsion, we found that liver cells significantly increased their omega-3 fatty acid content and experienced a noticeable reduction in fatty liver.
Our study suggests that bolus intravenous administration of this emulsion may quickly replenish omega-3s in liver cells, potentially correcting biochemical deficiencies. However, more research is needed to understand the full implications for liver disease treatment.
Read More
8
MCT may improve liver function
Medium-chain TAG attenuate hepatic oxidative damage in intra-uterine growth-retarded weanling piglets by improving the metabolic efficiency of the glutathione redox cycle.
We explored the impact of medium-chain triglycerides (MCT) on liver health in piglets facing challenges due to intra-uterine growth retardation (IUGR). By comparing piglets on a conventional soy oil diet with those receiving a diet rich in MCT, we observed that the latter group showed improved daily growth and feed efficiency.
Additionally, the MCT diet enhanced the liver's ability to manage oxidative damage, indicated by higher glutathione levels and reduced cell death in the liver. Overall, our findings suggest that MCT might offer a supportive therapy for young animals with liver stress.
It was astonishing from the very first spoon! I truly loved it. Its effect was evident immediately. Taking it on an empty stomach in the morning increased my energy levels throughout the day. It's excellent for athletes and anyone aiming to lose weight as it aids in entering ketosis swiftly. It's tasteless and easily digestible, making it perfect for those with liver disease and gallbladder issues. I experienced deep sleep and great concentration the following day after consuming it. However, it can act as a laxative in large doses, so I recommend starting slowly.
Read More
7.5
Easy absorption noted
6 people found this helpful
I highly recommend this oil; it does not hinder the body's absorption process as it passes directly through the liver, making it beneficial, according to a friend of mine.
Read More
9
Excellent training aid
This exceptional oil serves as a great alternative to many traditional oils and energy drinks. Packed with healthy fats, it’s absorbed in the intestines and goes directly to the liver, providing immediate energy. Taking a tablespoon before exercising significantly enhances my strength for workouts. I also enjoy adding it to smoothies, with its delicious coconut flavour and excellent quality.
Read More
7.5
Cleanses liver effectively
103 people found this helpful
I appreciated the cumin triglyceride form of this oil; it is excellent for cleansing the liver.
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7.5
Caution advised
4 people found this helpful
I consume about half a to two-thirds of a spoonful before bed or on an empty stomach due to concerns about straining my liver. Although it's a small amount, the flavour is noticeable. The MCT oil is swiftly absorbed by the liver, so if you have liver concerns, I suggest avoiding larger doses initially.
Liver disease encompasses a variety of conditions that affect the liver's ability to function effectively. The liver is a vital organ responsible for many important tasks, including metabolizing nutrients, detoxifying harmful substances, and producing bile for digestion. Common forms of liver disease include hepatitis, fatty liver disease, cirrhosis, and liver cancer. Each of these conditions can significantly impact liver function and overall health, leading to symptoms that range from fatigue and jaundice to more serious complications requiring urgent medical attention.
The causes of liver disease are diverse and can include chronic alcohol abuse, viral infections, autoimmune disorders, and metabolic conditions like obesity and diabetes. Early detection is key to managing liver disease effectively, often involving lifestyle changes, medications, and sometimes surgical interventions. Regular check-ups and liver function tests are recommended for individuals at higher risk, such as those with a family history of liver disease or those who lead certain lifestyle habits. Adopting a balanced diet and reducing alcohol intake can greatly aid in liver health and help prevent the onset of these conditions.
MCT oil is a supplement that has gained popularity in recent years, particularly among those following ketogenic or low-carb diets. MCT stands for medium-chain triglycerides, which are a type of fat that is more easily absorbed by the body compared to long-chain triglycerides found in many other dietary fats. MCT oil is typically derived from coconut oil or palm kernel oil and contains a high concentration of these medium-chain fatty acids, including caprylic acid (C8), capric acid (C10), and in some cases, lauric acid (C12).
The benefits of MCT oil include quick energy production, as the body can convert it into ketones, which are readily used as an energy source by the brain and muscles. Additionally, some studies suggest that MCT oil may aid in weight management by promoting a feeling of fullness and increasing metabolic rate. While MCT oil can be a great addition to smoothies, coffee, or salad dressings, it's important to introduce it gradually to your diet to avoid gastrointestinal discomfort. Always consult with a healthcare professional before making significant changes to your diet or supplement regimen.
Medium-chain triglyceride (MCT) oil has garnered attention for its potential health benefits, especially in the context of fat metabolism and energy production. Some studies suggest that MCT oil may have a supportive role in managing certain liver diseases due to its unique absorption and utilization in the body. Unlike long-chain fatty acids, MCTs are rapidly absorbed and transported directly to the liver, where they can be converted into energy rather than stored as fat. This property could potentially aid in improving liver function in specific cases, particularly in individuals with metabolic conditions.
However, it's crucial to approach MCT oil with caution, as research on its effects on liver disease is still emerging. While some evidence indicates potential benefits, such as improved lipid profiles and weight management, factors like individual health conditions, the severity of liver disease, and overall diet play significant roles in treatment. Always consult with a healthcare professional before incorporating MCT oil or any supplement into your regimen, especially if you have liver issues or other health concerns. More research is needed to establish firm guidelines, but MCT oil may provide some supportive benefits in specific contexts.
Based on user reviews, many individuals report experiencing noticeable effects from MCT oil shortly after consumption. For instance, one user mentioned feeling an increase in energy levels "from the very first spoon" and noted improvements in concentration and sleep quality (Read Review). Similarly, another reviewer emphasized that the oil is rapidly absorbed by the liver and provides immediate energy, particularly beneficial for those concerned with liver health (Read Review).
However, while immediate effects are reported in certain areas, individual experiences may vary, and it's often recommended to start with small doses, particularly for those with liver issues (Read Review). Users generally suggest incorporating MCT oil into the diet to see both short-term boosts in energy and potential long-term health benefits for liver support.
The use of medium-chain triglycerides (MCT) as a supplement for liver disease does seem to have some scientific backing, although the results are mixed. Research indicates that MCT oil can be effective in managing non-alcoholic fatty liver disease (NAFLD) by reducing liver fat and improving liver function in animal models, such as in a study that replaced corn oil with MCT in a rat diet, leading to reduced liver damage and fat accumulation [13]. Additionally, MCTs showed promise in reducing inflammation and liver injury in cases of alcohol consumption [14] and when assessed alongside a fish oil diet, indicating potential benefits for enhancing liver health [9].
However, it's essential to approach MCT supplementation with caution. Some findings have suggested that MCTs may worsen liver damage when coupled with high fructose diets, highlighting the potential risks involved [6]. Long-term use of MCT oil could lead to increased lipid accumulation in the liver [8], and some studies indicated no significant benefits in specific contexts [2]. Overall, while there are promising aspects to MCT oil for certain liver conditions, ongoing research is crucial for establishing clear guidelines regarding its safety and efficacy for liver health.
Users have reported a variety of improvements in symptoms after incorporating MCT oil into their diets. Many individuals noted significant boosts in energy levels, often feeling invigorated from their very first serving. For example, one user mentioned that taking MCT oil on an empty stomach in the morning heightened their energy throughout the day and contributed to better concentration and sleep quality (Read Review). Others also highlighted its immediate effects on workout strength, seeing it as a great pre-exercise supplement that enhances performance without causing fatigue (Read Review).
Additionally, several users praised MCT oil for its potential liver health benefits, noting that it helps regulate digestion and is gentle on those with liver issues due to its rapid absorption capabilities (Read Review). Some reviews specifically pointed out positive effects for individuals with fatty liver concerns, while others confirmed it aids in achieving ketosis for weight loss (Read Review). However, it’s worth noting that individual results can vary significantly, and some users advise starting with small doses to prevent any potential digestive discomfort (Read Review).
Based on user reviews, many individuals have reported positive experiences when combining MCT oil with other supplements or dietary practices for managing liver disease. Reviewers highlighted that MCT oil, due to its medium-chain fatty acids, bypasses traditional metabolic pathways and gets absorbed directly by the liver. This characteristic makes it beneficial for those with liver concerns, as noted by several users who experienced improved digestion and liver function, especially when taken in small doses (Read Review, Read Review).
Moreover, users have found MCT oil to be compatible with ketogenic diets, which could further assist in supporting liver health while providing an energy boost. Some reviewers mentioned using MCT oil in smoothies or coffee, emphasizing its versatility and ease of incorporation into various meal plans. However, caution was advised regarding dosage, as larger amounts could lead to digestive discomfort, underscoring the importance of starting with smaller quantities, especially for those with liver issues (Read Review).
Based on user reviews, the right dose of MCT oil for treating liver disease appears to vary, with many users emphasizing the importance of starting with smaller amounts. For instance, one user specifically noted that they consume about half to two-thirds of a spoonful before bed or on an empty stomach due to concerns about straining the liver, highlighting the recommendation to avoid larger doses initially Read Review. Another reviewer mentions taking one tablespoon daily, which they find beneficial for fatty liver hepatosis Read Review.
Additionally, users reported that MCT oil can provide quick energy, as it is absorbed directly by the liver and is considered beneficial for liver health Read Review, though some caution against larger amounts due to the potential laxative effect Read Review. Overall, starting with a moderate dose seems to be the consensus among users to ensure effective management of liver health without overwhelming the organ.
9
Boosted daily energy
7 people found this helpful
It was astonishing from the very first spoon! I truly loved it. Its effect was evident immediately. Taking it on an empty stomach in the morning increased my energy levels throughout the day. It's excellent for athletes and anyone aiming to lose weight as it aids in entering ketosis swiftly. It's tasteless and easily digestible, making it perfect for those with liver disease and gallbladder issues. I experienced deep sleep and great concentration the following day after consuming it. However, it can act as a laxative in large doses, so I recommend starting slowly.
9
Excellent training aid
This exceptional oil serves as a great alternative to many traditional oils and energy drinks. Packed with healthy fats, it’s absorbed in the intestines and goes directly to the liver, providing immediate energy. Taking a tablespoon before exercising significantly enhances my strength for workouts. I also enjoy adding it to smoothies, with its delicious coconut flavour and excellent quality.
7.5
Caution advised
4 people found this helpful
I consume about half a to two-thirds of a spoonful before bed or on an empty stomach due to concerns about straining my liver. Although it's a small amount, the flavour is noticeable. The MCT oil is swiftly absorbed by the liver, so if you have liver concerns, I suggest avoiding larger doses initially.
7.5
Gut regulation support
I use MCT oil in the mornings on an empty stomach, and it effectively regulates my digestion. It’s beneficial for the liver and fits well with a keto diet.
6
Useful for liver health
7 people found this helpful
I take one tablespoon daily, using it to season salads, add to coffee, or blend into smoothies. It’s beneficial for those with fatty liver hepatosis.
7.5
Easy absorption noted
6 people found this helpful
I highly recommend this oil; it does not hinder the body's absorption process as it passes directly through the liver, making it beneficial, according to a friend of mine.
8
MCT oil may mitigate liver disease
Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease.
We investigated how medium-chain triglycerides (MCT) might help tackle non-alcoholic fatty liver disease (NAFLD) in a rat model. By replacing corn oil with varying amounts of MCT oil in their diets, we found that increased MCT led to a significant reduction in liver fat and damage. This change also improved liver function without negatively affecting certain enzyme levels associated with liver health. While our findings are promising, it's essential to remember that further research is necessary to fully understand how MCT oil could help NAFLD in humans.
9
MCT reduces alcohol-related liver fat
Preservation of hepatocyte nuclear factor-4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats.
We examined the effects of medium chain triglycerides (MCT) on liver health, particularly in the context of alcohol consumption. Over eight weeks, male rats were fed diets containing control, alcohol, and MCT with alcohol.
The results showed that MCT reduced liver fat accumulation linked to alcohol while preserving critical liver proteins. MCT helped balance the fatty acid levels and normalized several liver genes affected by alcohol.
Ultimately, we found that MCT could offer liver protection from the harmful effects of alcohol by maintaining important cellular functions.
7
MCT may reduce inflammation
The addition of medium-chain triglycerides to a purified fish oil-based diet alters inflammatory profiles in mice.
We explored the impact of incorporating medium-chain triglycerides (MCT) into a fish oil-based diet on liver health in mice. By feeding six groups of mice different fat sources over twelve weeks, we assessed their inflammatory response following an endotoxin challenge.
Our findings suggest that adding MCT to fish oil may reduce inflammation, indicating a potential benefit for enhancing parenteral nutrition formulations. While this is promising, further research is necessary to confirm these effects in human applications.
2
MCT oil may harm liver health
Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice.
We explored how medium-chain triglyceride (MCT) oil affects liver health, particularly regarding damage caused by high fructose intake in mice. Over 12 weeks, we divided young mice into four groups to assess various health markers.
Surprisingly, we found that both groups receiving MCT oil exhibited liver issues, despite the expectation of improvement. The mice consuming fructose with MCT oil did not worsen the liver damage but still showed notable signs of hepatic steatosis and inflammation.
Overall, our findings suggest that MCT oil might lead to harmful liver effects, emphasizing the need for caution in its use, especially when liver health is already compromised.
7
MCT oil's mixed effects on liver
A rich medium-chain triacylglycerol diet benefits adiposity but has adverse effects on the markers of hepatic lipogenesis and beta-oxidation.
We explored the effects of a diet high in medium-chain triacylglycerol (MCT) on liver health and metabolism. Through a controlled study with mice over 12 weeks, we observed that while the highest MCT diet reduced body fat and improved insulin sensitivity, it also led to increased lipid accumulation in the liver.
This suggests that though MCT can have short-term benefits, long-term use might negatively impact liver function and metabolism. Thus, moderation is key when it comes to incorporating MCT oil into our diets, especially for those already managing liver conditions.
9
MCT oil improves GSD-1 outcomes
Medium-Chain Triglyceride Oil and Dietary Intervention Improved Body Composition and Metabolic Parameters in Children with Glycogen Storage Disease Type 1 in Jordan: A Clinical Trial.
We examined how medium-chain triglyceride (MCT) oil, combined with a specialized diet, influences children suffering from glycogen storage disease type 1 (GSD-1) in Jordan.
Over three months, we assessed 38 children and observed a dramatic reduction in hypoglycaemia, from nearly 95% to about 8%. There were also significant drops in triglycerides, cholesterol, and uric acid levels.
Importantly, we noted improvements in liver size and various growth parameters, indicating that MCT oil can positively impact metabolic health in this population.
References
Yue H, Jia M, Li B, Zong A, Du F, et al. Medium chain triglycerides alleviate non-alcoholic fatty liver disease through bile acid-mediated FXR signaling pathway: A comparative study with common vegetable edible oils. J Food Sci. 2024;89:10171. doi:10.1111/1750-3841.17565
Subih HS, Qudah RA, Janakat S, Rimawi H, Elsahoryi NA, et al. Medium-Chain Triglyceride Oil and Dietary Intervention Improved Body Composition and Metabolic Parameters in Children with Glycogen Storage Disease Type 1 in Jordan: A Clinical Trial. Foods. 2024;13. doi:10.3390/foods13071091
Wassef J, Lipkin E, Hardigan P, Duro D. Trends in liver profile and nutrition outcomes in children undergoing intestinal rehabilitation using a mixed lipid injectable emulsion. Nutr Clin Pract. 2022;37:1180. doi:10.1002/ncp.10782
Klek S, Szczepanek K, Scislo L, Walewska E, Pietka M, et al. Intravenous lipid emulsions and liver function in adult chronic intestinal failure patients: Results after 5 y of home parenteral nutrition. Nutrition. 2021;82:111029. doi:10.1016/j.nut.2020.111029
Baker MA, Cho BS, Anez-Bustillos L, Dao DT, Pan A, et al. Fish oil-based injectable lipid emulsions containing medium-chain triglycerides or added α-tocopherol offer anti-inflammatory benefits in a murine model of parenteral nutrition-induced liver injury. Am J Clin Nutr. 2019;109:1038. doi:10.1093/ajcn/nqy370
Guimarães J, Bargut TCL, Mandarim-de-Lacerda CA, Aguila MB. Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice. Prostaglandins Leukot Essent Fatty Acids. 2019;140:64. doi:10.1016/j.plefa.2018.11.005
Pereira-da-Silva L, Nóbrega S, Rosa ML, Alves M, Pita A, et al. Parenteral nutrition-associated cholestasis and triglyceridemia in surgical term and near-term neonates: A pilot randomized controlled trial of two mixed intravenous lipid emulsions. Clin Nutr ESPEN. 2017;22:7. doi:10.1016/j.clnesp.2017.08.007
Chamma CM, Bargut TC, Mandarim-de-Lacerda CA, Aguila MB. A rich medium-chain triacylglycerol diet benefits adiposity but has adverse effects on the markers of hepatic lipogenesis and beta-oxidation. Food Funct. 2017;8:778. doi:10.1039/c6fo01663d
Carlson SJ, Nandivada P, Chang MI, Mitchell PD, O'Loughlin A, et al. The addition of medium-chain triglycerides to a purified fish oil-based diet alters inflammatory profiles in mice. Metabolism. 2015;64:274. doi:10.1016/j.metabol.2014.10.005
Zhang H, Chen Y, Li Y, Yang L, Wang J, et al. Medium-chain TAG attenuate hepatic oxidative damage in intra-uterine growth-retarded weanling piglets by improving the metabolic efficiency of the glutathione redox cycle. Br J Nutr. 2014;112:876. doi:10.1017/S000711451400155X
Pichler J, Simchowitz V, Macdonald S, Hill S. Comparison of liver function with two new/mixed intravenous lipid emulsions in children with intestinal failure. Eur J Clin Nutr. 2014;68:1161. doi:10.1038/ejcn.2014.118
Zhong W, Li Q, Xie G, Sun X, Tan X, et al. Dietary fat sources differentially modulate intestinal barrier and hepatic inflammation in alcohol-induced liver injury in rats. Am J Physiol Gastrointest Liver Physiol. 2013;305:G919. doi:10.1152/ajpgi.00226.2013
Ronis MJ, Baumgardner JN, Sharma N, Vantrease J, Ferguson M, et al. Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease. Exp Biol Med (Maywood). 2013;238:151. doi:10.1258/ebm.2012.012303
Li Q, Zhong W, Qiu Y, Kang X, Sun X, et al. Preservation of hepatocyte nuclear factor-4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats. Alcohol Clin Exp Res. 2013;37:587. doi:10.1111/acer.12013
Carpentier YA, Peltier S, Portois L, Sebedio JL, Leverve X, et al. Rapid reduction of liver steatosis in omega3-depleted rats injected with a novel lipid emulsion. Horm Metab Res. 2008;40:875. doi:10.1055/s-0028-1083781
Lieber CS, DeCarli LM, Leo MA, Mak KM, Ponomarenko A, et al. Beneficial effects versus toxicity of medium-chain triacylglycerols in rats with NASH. J Hepatol. 2008;48:318.